Barrett's esophagus
Conditions
Interventions
None listed
Sponsors
Department of Gastroenteroogy and Hepatology, Amsterdam University Medical Centres (Amsterdam UMC)
Eligibility
Inclusion criteria
Inclusion criteria: - Aged between 18 and 75 years - Endoscopic and histological evidence of NDBE (defined as intestinal metaplasia without dysplasia) with a circumferential extent of =2 cm and a total maximum extent of =10 cm - Ability to provide a written informed consent
Exclusion criteria
Exclusion criteria: - Visible lesions in the esophagus suspicious for neoplasia during the first endoscopy (according to the Paris classification) - History of HGD or EAC in the esophagus - Unfit for endoscopic surveillance or inability to obtain biopsies - History of endoscopic or surgical treatment for esophageal dysplasia or EAC - History of esophageal surgery other than fundoplication - Presence of grade C or grade D erosive esophagitis (according to Los Angeles classification) - Refusal or inability to provide written informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Objective: To assess endoscopic and clinical risk factors for progression to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC) in a large prospective cohort of BE patients from community hospitals aiding objective risk stratification. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary Objectives: - To acquire high-resolution endoscopic images and videos to aid the training and validation of a CAD system to improve endoscopic detection of early neoplasia in BE patients. - To create a community-based BE surveillance registry to recruit patients for future studies. | — |
Contacts
Public ContactR.E. Pouw
Amsterdam UMC
Outcome results
None listed