Mechanical ventilation, sputum productgion
Conditions
Interventions
Patients will be randomized to either nebulisation of ipratropiumbromide (if age less than 4 years 125 micrograms, if age > 4 years then 250 micrograms) four times a day, endotracheal installation of
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: Children are eligible for inclusion if they meet the following criteria: 1. Pressure-controlled mechanical ventilation for at least 24 hours; 2. Endotracheal tube leakage < 5% (as measured by the mechanical ventilator); 3. Informed consent obtained from parents or legal caretakers.
Exclusion criteria
Exclusion criteria: 1. Mechanical ventilation less than 24 hours or children on high-frequency oscillatory ventilation; 2. Endotracheal tube leakage > 5%; 3. Pre-existing pulmonary abnormalities; 4. Pre-existing congenital heart disease with significant left-to-right shunt.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study the differences in changes in EELV between mechanically ventilated children after endotracheal suctioning with prior nebulisation of ipratropriumbromide, prior instillation of NaCl 0.9% or nothing. | — |
Secondary
| Measure | Time frame |
|---|---|
| To study the differences in PaO2/FiO2 and oxygenation index between mechanically ventilated children after endotracheal suctioning with prior nebulisation of ipratropriumbromide, prior instillation of NaCl 0.9% or nothing. | — |
Contacts
Public ContactM.C.J. Kneyber (UMCG)
Beatrix Children's Hospital/University Medical Center Groningen P.O. Box 30.001
Outcome results
None listed