Body composition (fat mass, fat free mass) Preterm infants Brain Growth Lichaamssamenstelling (vetmassa, vetvrije massa) Te vroeg geboren kinderen Hersenen Groei
Conditions
Interventions
None listed
Sponsors
Erasmus MC - Sophia Children's hospital
Eligibility
Inclusion criteria
Inclusion criteria: Preterm infants born before 30 weeks of gestation who are admitted to the NICU of the Erasmus MC within 48 hours after birth. Written informed consent
Exclusion criteria
Exclusion criteria: 1. Severe congenital and chromosomal anomalies 2. Perinatal asphyxia (defined as 5’min APGAR score below 5 and cord blood pH below 7.00) 3. Severe brain injury (defined by intraventricular hemorrhage grade III or IV, venous infarction or periventricular leucomalacia gr II or higher ) 4. Post hemorrhagic ventricular dilatation requiring lumbal punctures 5. Congenital TORCHES infections
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Body composition and brain growth assessed using cranial ultrasound or MRI and head circumference measurement at term equivalent age, 6 weeks and 6 months corrected age. Potential factors influencing the interaction between the brain and the gut (gut-brain axis): nutrition (enteral and parenteral nutrition, breastfeeding), feces (microbiome), saliva (microbiome, cortisol, ghrelin and leptin), hair (cortisol). Statistical adjustment for lifestyle factors (questionnaires) and clinical parameters. | — |
Primary
| Measure | Time frame |
|---|---|
| Body composition (percentage fat mass and fat-free mass) measured using air-displacement plethysmography and neurodevelopmental outcome assessed using Bayley Scales for Infant and Toddler Development, third edition and eye-tracking at 2 years corrected age. | — |
Contacts
Public ContactJorine A. Roelants
Wytemaweg 80
Outcome results
None listed