Parkinson's Disease
Conditions
Interventions
None listed
Sponsors
In this project we work together with patients and their representatives, MHeNs School for Mental Health and Neuroscience, Maastricht University Medical Centre (MUMC+), BioBank Maastricht UMC+ and Scannexus.
Eligibility
Inclusion criteria
Inclusion criteria: Participants are eligible for participation in this study if they meet the following criteria: 1) All patients have to be diagnosed with PD by a neurologist, within the last 3 years before inclusion. 2) A score of = 24 on the Montreal Cognitive Assessment (MoCA) at baseline. 3) Able to read and understand Dutch. 4) 18 years of age or older. 5) Providing written informed consent.
Exclusion criteria
Exclusion criteria: 1) Subjects with contra-indications for a MRI scan, such as claustrophobia or subjects carrying incompatible metallic devices such as pacemakers and certain mechanical valves. 2) Advanced cognitive impairment (MoCA <24) or dementia according to the DSM V criteria at baseline. 3) Subjects with other neurodegenerative diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -To determine early and subtle MRI changes in PD patients which distinguish them from the healthy population and to create a diagnostic tool for neurologists based on these differences. | — |
Secondary
| Measure | Time frame |
|---|---|
| - To detect whether different clinical phenotypes of PD patients also show different imaging characteristics. - To correlate MRI characteristics to clinical phenotype, genetic characteristics and progression of symptoms and thereby providing a prognostic tool for individual PD patients. | — |
Contacts
Public ContactAmée Wolters
Maastricht University Medical Centre+
Outcome results
None listed