A study on the efficacy of the combination of growth hormone and gonadotropin releasing hormone analogues (GnRHa) on adult height in children with idiopathic short stature.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON23928

Enrollment

Registered

2005-09-12

Start date

1993-10-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Idiopathic short stature or persistent short stature after being born small for gestational age.

Interventions

Daily injections of Growth Hormone (GH) and monthly injections with GnRHa (Decapeptyl) for 3 years. Regular controls at the clinic, blood investigations for effect and safety parameters, yearly X-ra

Eligibility

Inclusion criteria

Inclusion criteria: 40 adolescents in early puberty, with a height <-2 SDS or with a height SDS between -1 and -2, but a predicted adult height SDS <-2.

Exclusion criteria

Exclusion criteria: Disorders or medication influencing growth.

Design outcomes

Primary

Measure	Time frame
Final height SDS minus initial height SDS.	—

Secondary

Measure	Time frame
1. Final height SDS; 2. Final height SDS minus initial height SDS; 3. Final height SDS minus target height; 4. Body mass index; 5. Bone mineral density; 6. Quality of life.	—

Contacts

Public ContactJ.M. Wit

Leiden University Medical Center (LUMC), Department of Pediatrics, P.O. Box 9600

j.m.wit@lumc.nl+31 (0)71 5262824

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)