Improvement of fluid balance in patients undergoing surgery of the colon and rectum.

Does hemodynamic optimization during and after colorectal surgery result in improved intestinal perfusion, sustained intestinal barrier and improved postoperative recovery?

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON23916

Enrollment

Registered

2009-12-22

Start date

2010-02-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodynamic optimization, intestinal damage, ERAS, gastrointestinal disease. Hemodynamische optimalisatie, intestinale schade, ERAS, gastrointestinale aandoeningen.

Interventions

Fluid and/or noradrenaline administration based on cardiac output in/decrease and mean arterial pressure. The control group will receive standard care. The intervention group will receive standard c

Eligibility

Inclusion criteria

Inclusion criteria: 1. All patients undergoing elective colorectal surgery with anastomosis; 2. Minimum age 18 years; 3. Giving informed consent.

Exclusion criteria

Exclusion criteria: 1. Other causes of intestinal damage: IBD, occlusive disease; 2. Steroid use; 3. Esophageal varices and other esophageal disease; 4. Aortic valve disease.

Design outcomes

Secondary

Measure	Time frame
1. C-reactive protein (CRP) in plasma; 2. Liver Fatty Acid Binding Protein (L-FABP) in plasma and urine; 3. CO2 gap (arterial pCO2 - pCO2 stomach lumen); 4. Postoperative complications.	—

Primary

Measure	Time frame
Intestinal Fatty Acid Binding Protein (I-FABP) in plasma and urine.	—

Contacts

Public ContactKostan Reisinger

P. Debeyelaan 25

+31 (0)43 3882125

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)