Optimalisatie van intra-operatieve fluorescente beeldvorming van bijschildklieren.

Optimization of Intraoperative Near-Infrared Fluorescence Imaging of Parathyroid Adenomas using Low-Dose Methylene Blue.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON23886

Enrollment

Registered

2013-11-27

Start date

2012-10-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parathyroid adenoma, Near-infrared fluorescence imaging, Methylene blue

Interventions

Standard parathyroid adenoma resectino will be performed. Just before sugery of after opening the neck region, methylene blue will be injected intravenously to identify the parathyroid adenoma using N

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients diagnosed with primary hyperparathyroidism; 2. Age between 18 and 80.

Exclusion criteria

Exclusion criteria: 1. Allergy for Methylene blue; 2. Patients using SSRIs, SNRIs of TCAs; 3. Pregnancy; 4. Severe renal impairment; 5. Patients with a G6PD deficiency.

Design outcomes

Primary

Measure	Time frame
Intra-operative identification rate, defined as the number of adenomas that were identified with the fluorescent signal of methylene blue during operation.	—

Secondary

Measure	Time frame
Tumor-to-background signal of the identified adenomas.	—

Contacts

Public ContactC.J.H. Velde, van de

Leiden University Medical Center (LUMC), Department of Surgical Oncology, P.O. Box 9600

c.j.h.van_de_velde@lumc.nl+31 (0)71 5262309

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)