Obesity.
Conditions
Interventions
Saline (control) or a 5 g emulsion consisting either of mainly unsaturated fats (18:0), mono-unsaturated fat (18:1) or di-unsaturated fat (18:2) will be administered to the ileum on 4 consecutive days
Sponsors
LUMC - Dept of Gastroenterology - Hepatology
PO box 9600
2300 RC Leiden
fax nr.:0715248115
tel. nr.:0715263507
Eligibility
Inclusion criteria
Inclusion criteria: 1. Signed informed consent form; 2. Sex: male or female; 3. Age: 18-55 years; 4. Body Mass Index (BMI): 18-32 kg/m2.
Exclusion criteria
Exclusion criteria: 1. Evidence of severe cardiovascular, respiratory, urogenital, gastrointestinal/ hepatic, hematological/immunologic, HEENT (head, ears, eyes, nose, throat), dermatological/connective tissue, musculoskeletal, metabolic/nutritional, endocrine, neurological/psychiatric diseases, allergy, major surgery and/or laboratory assessments which might limit participation in or completion of the study protocol; 2. Gastrointestinal or hepatic disorders influencing gastrointestinal absorption or transit; 3. The use of psychotropic drugs, including: benzodiazepines or alcohol in excess of 21 units/week for males and 14 units/week for females; 4. Concomitant medication that can increase gastric pH (e.g. antacids, protonpump-inhibitors, prostaglandins, anticholinergic agents, H2-receptor antagonists), or alter gastric emptying (e.g. metoclopramide, cisapride, domperidone and erythromycin, anticholinergics, tricyclic antidepresants, narcotic analgetics, adrenergic agents, calcium channel blockers), or alter intestinal transit (e.g. loperamide, chemical/osmotic/bulk laxatives) ,or influence satiety/energy intake (e.g. sibutramine, glucocorticoids, anabolic steroids); 5. Intolerance of Slim Fast product or of ingredients of the ad libitum meal; 6. Pregnancy, lactation, wish to become pregnant during study, or having a positive pregnancy test at inclusion; 7. Reported unexplained weight loss/gain of more than 2 kg in the month before the study enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess whether emulsions differing in degree of saturation, have different effects when administered in the ileum, on satiety as measured by visual analogue scales, and food intake during ad libitum lunch. | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the effect of emulsions differing in degree of saturation, when infused in the ileum on gastric emptying, intestinal transit time and on secretion of peptides known to affect satiety. Peptides we will measure are Ghrelin and CCK as proximal gut hormones and Apo A-IV and PYY as distal gut hormones (ileal brake). | — |
Contacts
Public ContactP.W.J. Maljaars
University Hospital Maastricht (azM) Department of Internal Medicine Divison of Gastroenterology & Hepatology PO Box 5800
Outcome results
None listed