depression
Conditions
Interventions
REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION daily on 10 consecutive weekdays (five sessions per week), during 20 minutes per session.
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: In and outpatients aged between 16 and 65 who met DSM-IV criteria for major depressive episode, and who had a score of 25 or higher on the 10-item Montgomery Asberg Depression Rating Scale (MADRS) were included.
Exclusion criteria
Exclusion criteria: Exclusion criteria were a history of epilepsy and any other medical disorder that should preclude the administration of rTMS. Only SSRI's, Mirtazapine and Promethazine as psychotropic medication was accepted if the dosage of antidepressive medication had not been changed for 6 weeks, and if the dosage of Promethazine had not been changed for 2 weeks prior to inclusion. Antidepressive medication had to remain stable during the 14 weeks of the study. Furthermore: schizofrenic disorder, a piece if metal in the brain, pacemaker and left-handed patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Changes in anxiety; 2. Autonomic changes; 3. Changes in the emotioneal attention, in the emotional memory en in de emotional recognition; 4. Biochemical changes; 5. Changes in the EEG. | — |
Contacts
Public ContactJ. Riet, van der
St. Lucas Andreas Hospital, Department of Psychiatry, Jan Tooropstraat 164
Outcome results
None listed