Endoscopic surveillance using narrow-band imaging in patients with hyperplastic polyposis syndrome (HPS): A multi-centre cohort study.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON23826

Enrollment

Registered

2010-09-03

Start date

2010-10-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hyperplastic Polyposis Syndrome Narrow Band Imaging

Interventions

All patients will undergo tandem colonoscopy with HRE and NBI, in randomized order with removal of all detected polyps &#8805

3 mm after characterization for Kudo pit pattern and vascular pattern intensity (VPI).

Eligibility

Inclusion criteria

Inclusion criteria: All HPS patients, defined as having: 1. ≥5 HPs/SSAs proximal to the sigmoid colon of which 2 are greater than 10mm in diameter or; 2. ≥20 HPs/SSAs spread throughout the colon.

Exclusion criteria

Exclusion criteria: 1. Patients carrying a germline mutation in the MutYH (biallelic) or APC gene and individuals who have undergone a total colonic resection; 2. History of inflammatory bowel disease; 3. Severe coagulopathy; 4. Age less than 18 years and; 5. Insufficient bowel preparation (<90% of colonic mucosa visible).

Design outcomes

Primary

Measure	Time frame
Polyp miss-rates of NBI vs. HRE.	—

Secondary

Measure	Time frame
The diagnostic accuracy of NBI-VPI vs. HRE-VPI for the differentiation of polyps.	—

Contacts

Public ContactY. Hazewinkel

Meibergdreef 9

y.hazewinkel@amc.uva.nl+31 (0)20 5662806

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)