Evaluation of the clinical impact of ventricular dyssynchrony in patients with corrected tetralogy of fallot

Evaluation of the effect of pulmonary valve replacement on ventricular dyssynchrony in young patients with corrected tetralogy of fallot

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON23806

Enrollment

Registered

2008-07-23

Start date

2008-07-23

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tetralogy of Fallot (tetralogie van Fallot), pulomnary valve replacement (pulmonaalklepvervanging) ventricular dyssynchrony (ventrikel dyssynchronie)

Interventions

Group: patients with corrected Tetralogy of Fallot who undergo pulmonary valve replacement. Intervention: pulmonary valve replacement (PVR), surgical or percutaneous

Eligibility

Inclusion criteria

Inclusion criteria: 1. Corrected tetralogy of fallot 2. >8 year 3. Scheduled for pulmonary valve replacement

Exclusion criteria

Exclusion criteria: 1. Claustrophobia 2. Renal disease 3. Cardiac arrythmia

Design outcomes

Primary

Measure	Time frame
Primary outcome: Differences in time to peak systolic velocity between different segments of the right ventricle: - Right ventricular outflow tract - Right ventricular free wall - Right ventricular septum. The greatest difference in time to peak systolic velocity of the segments (latest peak systolic velocity minus earliest peak systolic velocity) will be used as a measure of dyssynchrony, and this value will be compared before and after PVR	—

Measure

Time frame

Primary outcome: Differences in time to peak systolic velocity between different segments of the right ventricle: - Right ventricular outflow tract - Right ventricular free wall - Right ventricular septum. The greatest difference in time to peak systolic velocity of the segments (latest peak systolic velocity minus earliest peak systolic velocity) will be used as a measure of dyssynchrony, and this value will be compared before and after PVR

—

Secondary

Measure	Time frame
Effect of PVR on ventricular function (eg. volume, diastolic function, E/A ratio, pulmonary regurgitation, Vo2 max, clinical condition)	—

Contacts

Public ContactA.E. Hulst, van der

Leiden University Medical Center Willem Alexander Kinder- en Jeugdcentrum Peadiatric Cardiology P.O. box 9600

a.e.van_der_hulst@lumc.nl+31 (0)71 5261593

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)