Twin cohort for the study of (pre)clinical Inflammatory Bowel Disease in the Netherlands The TWIN-study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON23799

Enrollment

444

Registered

2017-08-07

Start date

2017-09-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammatory Bowel Disease IBD M. Crohn Crohn's disease ziekte van Crohn Ulcerative colitis colitis ulcerosa twin tweeling preklinisch preclinical

Interventions

This is an observational cohort study, designed to explore factors possibly contributing to the pathogenesis of Inflammatory Bowel Disease. From all participants the following data will be collect

Eligibility

Inclusion criteria

Inclusion criteria: Inclusion criteria for IBD-discordant and IBD-concordant twins or multiples: - Born as a sibling of, either a monozygous or dizygous, twin pair or multiplex - One or more twin-siblings are affected with IBD, i.e. CD, UC or IBD unspecified (confirmed by clinical, endoscopic and histological features) - Age: 16 years and older Inclusion criteria for the unaffected controls (preferably twins or multiples): - None of the siblings of the twin are affected with IBD, i.e. CD, UC or IBD unspecified - Age: 16 years and older

Exclusion criteria

Exclusion criteria: - No consent to participate in the study.

Design outcomes

Primary

Measure	Time frame
The association of the following factors with established and preclinical IBD will be studied: - Environmental factors - Early signs and symptoms of IBD development - Immunological phenotyping and function - Gut and oral microbiota anlayses - Metabolome analyses - Mucus barrier analyses - Epithelium analyses - DNA-sequencing analyses	—

Contacts

Public ContactEelco Brand

kamernummer L00.418

E.C.Brand-4@umcutrecht.nl+31 88 755 9682

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)