Brown adipose tissue activity and bile acids

The role of bile acids in human brown adipose tissue metabolism

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON23736

Enrollment

Registered

2013-10-03

Start date

2013-10-01

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy young men and women

Interventions

The study will include three laboratory visits for each individual, in which BAT activity will be measured. During one visit BAT activity and EE will be determined after administration of CDCA. On ano

Eligibility

Inclusion criteria

Inclusion criteria: -Caucasians -Age: 18-30 years -Gender: male and female (females only on a specific oral contraceptive pill; microgynon 30 or levonorgestrel/ethinylestradiol) -BMI: 18-25 kg/m2 -Good general health

Exclusion criteria

Exclusion criteria: -Psychologically unstable subjects (as judged by the treating medical specialist) -Subjects with mental retardation (as judged by the treating medical specialist) -Subjects with severe behavior disorders (as judged by the treating medical specialist) -Pregnancy or lactation -The use of the following medication one month before the study is an exclusion criterium; ß-blockers, ursodeoxycholic acid, bile acid sequestrants and antacida -Participation in an intensive weight-loss program or vigorous exercise program during the last year before the start of the study -Abuse of drugs and/or alcohol -Severe diabetes which requires application of insulin or patients with diabetes-related complications -Surgery of the gastro-intestinal tract (only appendectomy is allowed) -Previous ERCP with papillotomy -History of cholesystectomy or disease of the gallbladder, biliary system and/or liver -Hyperthyroidism or hypothyroidism -BMI > 25 kg/m2 -Participation in earlier research or medical examinations that included PET/CT scanning

Design outcomes

Primary

Measure	Time frame
- Energy expenditure - Brown adipose tissue activity	—

Secondary

Measure	Time frame
- Skin temperature - Core temperature - Body composition - Skin perfusion	—

Contacts

Public ContactE.P.M. Broeders

Maastricht University, Dept of Human Biology

e.broeders@maastrichtuniversity.nl+31 43 3884260

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)