aneurysmal subarachnoid hemorrhage
Conditions
Interventions
In the intervention group, subjects will receive acetazolamide intravenously as well as treatment as usual. The dosage of acetazolamide will be similar to the average dosage used for the treatment of
Sponsors
University Medical Center Utrecht
Eligibility
Inclusion criteria
Inclusion criteria: ≥18 years old Aneurysm confirmed by the presence of subarachnoid blood by computed tomography (CT) or lumbar puncture and by visualization of the aneurysm on either CT angiography, MR angiography or digital subtraction angiography Hospital arrival ≤72 hours of ictus Eligible for aneurysm coiling
Exclusion criteria
Exclusion criteria: Intensive care (IC) required for >72 hours after ictus (i.e., during inclusion window) Perimesencephalic bleeding Traumatic SAH Severe liver dysfunction or severe renal dysfunction Allergic reaction for sulfomides Any contraindication for MR imaging (e.g. metal objects within or around the body) Pregnancy or women who are breastfeeding Addison’s disease Phenytoin use
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebral perfusion (arterial spin labeling (ASL) MRI) on day 7±2 after ictus. | — |
Secondary
| Measure | Time frame |
|---|---|
| Cerebral perfusion (arterial spin labeling (ASL) MRI) on day 12±2 after ictus. Serious adverse events (SAEs) and serious unexpected serious adverse reactions (SUSARs) until 10 weeks after ictus. The occurrence of DCI. DCI will be defined as either “clinical deterioration or cerebral infarction due to delayed cerebral ischemia”. | — |
Contacts
Public ContactLisa van der Kleij
Postbus 85500
Outcome results
None listed