Hypopituitarism in patients after subarachnoid hemorrhage
Conditions
Interventions
Replacement of hormone defeciencies as required.
Sponsors
erasmus medical centre
Eligibility
Inclusion criteria
Inclusion criteria: 1. Subarachnoid hemorrhage; 2. Signed and dated informed consent document.
Exclusion criteria
Exclusion criteria: Subjects with any of the following items will be excluded from the study: 1. Any hypothalamic/pituitary disease diagnosed prior to SAH; 2. History of cranial irradiation; 3. Prior significant trauma capitis; 4. Another significant intracranial lesion (apart from SAH or its sequellae); 5. Any other medical or psychiatric condition or laboratory abnormality that may impose a risk for participation in the study or interfere with the interpretation of the study (according to the judgment of the investigators).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To determine the prevalence of hypopituitarism in patients after SAH; 2. To identify neurological parameters that predict hypopituitarism after SAH; 3. To determine the value of a Ghrelin test shortly after SAH, to identify subjects with GHD. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To determine the impact of hypopituitarism on physical functioning, activity pattern and participation; 2. To evaluate the effect of GH replacement on residual functional physical fitness, fatigue and quality of life. | — |
Contacts
Public ContactF. Kooten, van
's Gravendijkwal 230
Outcome results
None listed