Pharmacokinetics of 6-thioguanine.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON23696

Enrollment

Registered

2005-08-16

Start date

2005-06-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Crohn's disease of ulcerative colitis (IBD).

Interventions

Blood draws.

Eligibility

Inclusion criteria

Inclusion criteria: 1. IBD; 2. In need of immunosuppressants; 3. Intolerant to azathioprine or methotrexate.

Exclusion criteria

Exclusion criteria: 1. Concomittant use of drugs interfering with thiopurine metabolism; 2. Pregnancy/lactation.

Design outcomes

Primary

Measure	Time frame
Determination of first pass effect of 6TG metabolites.	—

Secondary

Measure	Time frame
Determination of influence of different enzymes on 6TG metabolism.	—

Contacts

Public ContactK.H.N. Boer, de

VU University Medical Center, Department of Gastroenterology and Hepatology, P.O. Box 7057

KHN.deBoer@vumc.nl

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)