Accelerated vascular ageing Chronic kidney disease Type 2 diabetes
Conditions
Interventions
Not applicable.
Sponsors
University Medical Center Groningen
Eligibility
Inclusion criteria
Inclusion criteria: Kidney donors: - Men and women - Age above 17 years Kidney recipients: - Men and women - Age above 17 years - Kidney failure leading to transplantation
Exclusion criteria
Exclusion criteria: - Inadequate spreaking of Dutch language - Age below 18 years - Incompetent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| •Characterization of the pro-inflammatory and pro-calcifying environment of PVAT as compared to subcutaneous fat (SAT) •Identification of potential differences in inflammatory profile between PVAT obtained from ‘healthy’ and calcified arterial wall •Assessment of the effects on SMC calcification, dedifferentiation and contractile function in vitro of PVAT (compared to SAT) | — |
Secondary
| Measure | Time frame |
|---|---|
| - Role of type 2 diabetes mellitus in PVAT dysfunction - Differences between end-stage renal disease and pre-emptive renal transplant recipients in its role of PVAT dysfunction | — |
Outcome results
None listed