Tetanus prophylaxis.

Tetanus post-exposure prophylaxis.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON23665

Enrollment

800

Registered

2012-07-16

Start date

2012-10-01

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

tetanus prophylaxis after wounding on emergency department

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: 1. Participants need to be at least 18 years old; 2. Participants with all types of wounds visiting one of the three emergency departments.

Exclusion criteria

Exclusion criteria: 1. Patients younger than 18 years old; 2. Patients with severe injuries requiring immediate care or surgery.

Design outcomes

Primary

Measure	Time frame
The main study endpoint will be the immune status as determined by the TQS (adequately protected versus insufficient protected), cut-off 0.1 IU/ml. and the use of tetanus post- exposure prophylaxis (yes/no). The immune status as assessed by the TQS will be related to the anamnestic vaccination history, i.e. adequately immunized with time since the last vaccination (more or less than 10 years since the last vaccination) or not or incompletely immunized. Over- and under-prescription of tetanus post-exposure prophylaxis will be assessed both for tetanus vaccination and TIG. A comparison will be made between the immune status determined by the vaccination history and the immune status as a result of the TQS. A questionnaire will be used to record the vaccination status determined by the attending health care professional during anamnestic history. The frequency of over- and under-prescription of post-exposure prophylaxis will be determined. The indication for post-exposure prophylaxis will be based on the advice of the Dutch National Health Council (GR) in 2003 that is the basis of the current nationwide guidelines. The immune status due to the result of the TQS test will be stated as protected or unprotected. There will be a distinction between the two different age cohorts as mentioned earlier, born before 1951 or after 1950. The two age cohorts will be distinguished to assess the relation between tetanus prophylaxis (tetanus vaccination and TIG) and the result of TQS.	—

Measure

Time frame

The main study endpoint will be the immune status as determined by the TQS (adequately protected versus insufficient protected), cut-off 0.1 IU/ml. and the use of tetanus post- exposure prophylaxis (yes/no). The immune status as assessed by the TQS will be related to the anamnestic vaccination history, i.e. adequately immunized with time since the last vaccination (more or less than 10 years since the last vaccination) or not or incompletely immunized. Over- and under-prescription of tetanus post-exposure prophylaxis will be assessed both for tetanus vaccination and TIG. A comparison will be made between the immune status determined by the vaccination history and the immune status as a result of the TQS. A questionnaire will be used to record the vaccination status determined by the attending health care professional during anamnestic history. The frequency of over- and under-prescription of post-exposure prophylaxis will be determined. The indication for post-exposure prophylaxis will be based on the advice of the Dutch National Health Council (GR) in 2003 that is the basis of the current nationwide guidelines. The immune status due to the result of the TQS test will be stated as protected or unprotected. There will be a distinction between the two different age cohorts as mentioned earlier, born before 1951 or after 1950. The two age cohorts will be distinguished to assess the relation between tetanus prophylaxis (tetanus vaccination and TIG) and the result of TQS.

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Contacts

Public ContactRobine Donken

National Institute for Public Health and the Environment (RIVM) Centre for Infectious Disease Control Epidemiology and Surveillance Unit PObox 1 (Pb.75)

robine.donken@rivm.nl+31 (0)30 2744378

Outcome results