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Sugar, non-caloric sweeteners and reward.

Sugar, non-caloric sweeteners and reward.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
NL-OMON
Registry ID
NL-OMON23659
Enrollment
40
Registered
2012-02-14
Start date
2012-03-26
Completion date
Unknown
Last updated
2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Eating behaviour

Interventions

In the conditioning period (5 days a week for 4 weeks), subjects will be offered a sugar sweetened or a non-caloric sweetened version of either a yoghurt drink or a soft drink 10 times in random order

Sponsors

Wageningen University, Department of Human Nutrition
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age: 18-35 years; 2. BMI: 18.5 – 25.0 kg/m2; 3. Healthy (as judged by the participant).

Exclusion criteria

Exclusion criteria: 1. Restraint eating (men: score > 2.25; women: score > 2.80); 2. Lack of appetite; 3. Having difficulties with swallowing/eating; 4. Usage of an energy restricted diet during the last two months; 5. Weight loss or weight gain of 5 kg or more during the last two months; 6. Stomach or bowel diseases; 7. Diabetes, thyroid disease, other endocrine disorders; 8. Having a history of neurological disorders; 9. Having taste or smell disorders; 10. Usage of daily medication other than birth control pills; 11. For females: Being pregnant or lactating; 12. Smoking more than one cigarette a day; 13. Being allergic/intolerant for products under study; 14. Exclusive consumption of ‘light’ versions of yoghurt and/or soft drinks; 15. Working at the division of human nutrition (WUR); 16. Current participation in other research from the division of human nutrition (WUR); 17. For males: Having a contra-indication to MRI scanning (including, but not limited to): A. Claustrophobia; B. Epilepsy or a family history of epilepsy; C. Serious physical or mental illnesses; D. Pacemakers and defibrillators; E. Intraorbital or intraocular metallic fragments; F. Ferromagnetic implants; G. Presence of any other metal object e.g. in the mouth; H. Being lefthanded.

Design outcomes

Primary

MeasureTime frame
The primary objective of this study is to determine the effect of replacing added sugar by non-caloric sweeteners in a nutrient-rich matrix (dairy drink yoghurt) and in a nutrient-empty matrix (soft drink) on reward value reflected in preferences and brain responses after repeated exposure.

Secondary

MeasureTime frame
The secondary objective of this study is to determine the effect of replacing added sugar by non-caloric sweeteners in a nutrient-rich matrix (dairy drink yoghurt) and in a nutrient-empty matrix (soft drink) after repeated consumption on: 1. Explicit and implicit liking and wanting of these products; 2. Implicit associations of these products with feelings of satiety; 3. Expected satiety of these products; 4. Ad libitum intake of these products.

Contacts

Public ContactS. Griffioen-Roose

Wageningen University Division of Human Nutrition PO Box 8129

sanne.griffioen-roose@wur.nl+31 (0)317 485897

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)