Among IVF-ICSI patients with poor implantation, does PGS increase pregnancy rates and live birth rates?

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON23652

Enrollment

200

Registered

2008-06-11

Start date

2001-11-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

PGS, recurrent implantation failure, IVF-ICSI

Interventions

In both groups, patients underwent controlled ovarian hyperstimulation. IVF-ICSI was perfomed in every study patient. On day three of the embryonic development, preimplantation genetic diagnosis was p

Eligibility

Inclusion criteria

Inclusion criteria: 1. Subfertility with need for ART with motile sperm 2. Three or more failed IVF or ICSI attempts with embryos of good morphological quality 3. Maternal age less than 38 years 4. A normal karyotype in both partners.

Exclusion criteria

Exclusion criteria: 1. Maternal age above 38 years. 2. Presence of uterine pathology

Design outcomes

Primary

Measure	Time frame
The primary outcome is the implantation rate, which is defined as the ratio between the number of gestational sacs with a fetal heartbeat and the total number of embryos transferred.	—

Secondary

Measure	Time frame
Secondary endpoints are embryo morphology and chromosomal status, number of transferred embryos and clinical pregnancy rate.	—

Contacts

Public ContactChristophe Blockeel

Universitair Ziekenhuis Brussel Centre for Reproductive Medicine

cblockee@uzbrussel.be

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)