Intestinal failure
Conditions
Interventions
Directly after collection of the first sets of blood cultures, two EDTA blood samples of 5 mL will be collected from the CVC and two 5 mL EDTA blood samples will be collected from the peripheral veins
Sponsors
MLDS
Eligibility
Inclusion criteria
Inclusion criteria: • Clinical suspicion of a bloodstream infection. • Written informed consent before entering study.
Exclusion criteria
Exclusion criteria: • Intestinal failure patients <18 years of age.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome is the sensitivity of the ddPCR to detect pathogens in blood compared with the gold standard. | — |
Secondary
| Measure | Time frame |
|---|---|
| • Specificity of ddRST. • Positive/negative predictive values of ddRST • Positive/negative likelihood ratios of ddRST. • Sensitivity/specificity of ddRST: o in patients who received antibiotics =3 days before presentation. o in patients who received antibiotics =7 days before presentation. o for detecting Gram-positive bacteria. o for detecting Gram-negative bacteria. o for detecting fungi. o in relation to sepsis severity (sepsis versus septic shock) o compared to follow-up bloodcultes | — |
Contacts
Public ContactVeerle Gillis
Radboud umc
Outcome results
None listed