Hemophilia Vascular calcification Media sclerosis Peripheral arteries Arterial stiffness
Conditions
Interventions
Subjects will remain in our study centre for no longer than four hours. MRI scanning will be performed, followed by analysis of pulse wave velocity. Next blood will be drawn and measurement of height,
Sponsors
University Medical Center Groningen
Eligibility
Inclusion criteria
Inclusion criteria: 1. Hemophilia A and B patients 2. Written informed consent for study participating 3. Males, 18 years and older 4. Documented ABI >0.9
Exclusion criteria
Exclusion criteria: 1. Patients with symptomatic atherosclerotic disease or history of arterial thrombotic events. 2. Patients with chronic kidney disease (CKD), defined as eGFR < 60 ml/ min, calculated according to the Modification of Diet in Renal Disease formula. 3. Patients with diabetes mellitus, defined as any history of diabetes or current diabetes (diagnosed by HbA1c ¡Ý 6.5% according to the American Diabetes Association diagnostic criteria). 4. Patients with any contraindication to MRI (pacemaker or claustrophobia).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Peripheral artery MRI characteristics (wall thickness, media thickness and stiffness) in hemophilia patients with a normal ankle brachial index and in hemophilia patients with a high ankle brachial index. 2. Carotid-(right) femoral pulse wave velocity and carotid-(left) radial pulse wave velocity in both groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Relation between vessel wall characteristics, arterial stiffness and traditional cardiovascular risk factors. 2.Relation between vessel wall characteristics, arterial stiffness and severity of haemophilia. | — |
Contacts
Public ContactHilde Hop
Vascular Medicine - University Medical Center Groningen
Outcome results
None listed