Anesthesiology, PKPD modeling
Conditions
Interventions
This is a validation study where patients from a broad population (age-range, lean and obese) receive TCI propofol using the Eleveld model. Blood samples will be taken to measure plasma concentrations
Sponsors
University Medical Center Groningen
Eligibility
Inclusion criteria
Inclusion criteria: - 3 years and older - American Society of Anesthesiologists (ASA) physical status 1-4 - Elective surgical procedure with an expected duration of 1 hour or more. - Need for an arterial line placement for the procedure - Written informed consent
Exclusion criteria
Exclusion criteria: - Contraindication for the use of propofol (i.e. allergy) - Inclusion in other studies preventing the use of propofol as primary hypnotic agent - Patients who have been admitted to the intensive care unit prior to surgery and/or have received propofol as sedation or anaesthesia in the 24 hours before the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Performance criteria (performance error, median (absolute) performance error, divergence, wobble) assessing the performance of the Eleveld PKPD model in the studied population. | — |
Contacts
Public ContactR. Spanjersberg
Hanzeplein 1
Outcome results
None listed