Cerebral blood flow measurements with fMRI.

The effect of a liquid meal on cerebral lood flow in healthy lean individuals measured with (1 tesla) fMRI: A pilot study.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON23542

Enrollment

Registered

2010-05-04

Start date

2010-05-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bestuderen van de bloeddoorstroming van de hersenen in reactie op een hoog calorische stimulus. To study cerebral blood flow with 1Tesla MRI before and after ingestion of a liquid meal.

Interventions

Ingestion of a high-caloric liquid meal.

Eligibility

Inclusion criteria

Inclusion criteria: 1. 15 lean male subjects/ 15 lean female subjects; 2. BMI 20- 25 kg/m²; 3. Age 18 – 60 years; 4. Stable weight 3 months prior to study inclusion; 5. Caucasian; 6. Written informed consent; 7. Right handed.

Exclusion criteria

Exclusion criteria: 1. Claustrophobia; 2. Metal objects in the body (e.g. pacemaker); 3. Left handed; 4. Smoking and/or Alcohol/Drug abuse; 5. Intensive exercise (more than 3 times per week); 6. Eating disorder (other DSM IV diagnosis); 7. Medication use that interferes with dopamine metabolism or nutrient absorption; 8. DM.

Design outcomes

Primary

Measure	Time frame
Percentage and/or absolute changes in local cerebral blood flow after a liquid meal.	—

Secondary

Measure	Time frame
1. Difference in cerebral blood flow between males and females; 2. Influence of ingestion of a liquid meal.	—

Contacts

Public ContactB.A.M. Weijer, de

Academic Medical Center (AMC) Department of Endocrinology and Metabolism P.O. Box 22660 1100 DD

B.A.deWeijer@amc.uva.nl+31 (0)20 5666849

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)