Hypoxia
Conditions
Interventions
Healthy volunteers will each be seen for three sessions, with 2 weeks in between. Hypoxia will be induced using the computer driven Dynamic End-Tidal Forcing (DEF) Technique
end-tidal oxygen concentrations will be lowered to 5.8 kPa (about 45 mmHg) to reach an oxygen saturation of 80 ± 2 %, whereas the PCO2 level remains constant (end-tidal concentration is rest endtidal
P max) will be measured using Doppler echocardiography. An arterial line will provide information about the arterial blood gas and BP. Each time one substance, either NaCl 0,9%, Erythropoietin or ARA2
Sponsors
Leiden University Medical Center (LUMC)
Eligibility
Inclusion criteria
Inclusion criteria: The major inclusion criteria is that the subject has echo evidence of tricuspid regurgitation during systole, which is not clinically relevant but in fact can be demonstrated in most normal individuals.
Exclusion criteria
Exclusion criteria: 1. Obesity (BMI > 35); 2. Presence of medical disease (heart-, lung-, liver-, kidney-, neurologic disease; diabetes m.; pyrosis; diaphragmatic hernia); 3. Presence of psychiatric disease; 4. History of chronic alcohol or illicit drug use; 5. Allergy to study medications. For females we require the use of oral contraceptives.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Hypoxic Ventilatory Response (HVR); 2. Pulmonary Artery Pressure (PAP). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Systolic and diastolic cardiac functions; 2. Vital and ventilatory parameters; 3. Pain thresholds under hypoxia. | — |
Contacts
Public ContactR.R. Berendsen
Dept. of Anesthesiology LUMC, P5-Q
Outcome results
None listed