Primary acute stroke (including both cerebral infarction and hemorrhage)
Conditions
Interventions
- 2x 3T MRI scan
- Blood sampling via venipuncture
- Neurological evaluation up to one year
Sponsors
Academic hospital Maastricht (azM)
Eligibility
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: • Diagnosed with a primary acute stroke (including both cerebral infarction and hemorrhage) • A SeLECT score = 5 or a CAVE score = 2 • Age of = 18 years
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: • Contradictions for a gadolinium-based contrast agent (known allergy or insufficient kidney function determined by an eGFR = 30 mL/min) • Contradictions for MRI scanning (e.g. metal implants, cardiac pacemaker, claustrophobia, pregnancy) • Previous history of stroke, epileptic seizures or other cerebral disorders (e.g. neurodegenerative diseases or head/brain tumors) • Re-infarction during follow-up • Potential epileptogenic co-morbidities (e.g. alcohol or drugs abuse, cerebral venous thrombosis, history of brain surgery) • Absence of written informed consent (by a legal representative)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The differences in blood-brain barrier integrity of patients who will or will not develop epilepsy after stroke. | — |
Secondary
| Measure | Time frame |
|---|---|
| The pathophysiological changes in the brain after stroke, and how these changes are related to the development of epilepsy after stroke. | — |
Contacts
Public ContactElles Elschot
Maastricht University Medical Center+
Outcome results
None listed