Rotterdam Aphasia Therapy Study-3: The efficacy of early, intensive cognitive-linguistic therapy in aphasia after stroke (a randomized controlled trial).

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON23495

Enrollment

150

Registered

2012-01-13

Start date

2011-01-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

aphasia afasie stroke beroerte

Interventions

Experimental group: Intensive cognitive-linguistic language therapy

semantic and/or phonologic: 1. Semantic therapy with the cognitive-linguistic program BOX (E.G. Visch-Brink, I.M. Bajema, 2001) including a digital version: eBOX

2. Phonological therapy with the cognitive-linguistic program FIKS (M. van Rijn, L. Booy, E.G. Visch-Brink, 2000), including a digital version: eFIKS. Intensity: 7 hours a week (1 hour a day), of whi

thus maximum at six weeks after the stroke. All patients who meet the additional criteria will be asked to participate in a neuroimaging study subpart of RATS-3, FIAT, (Functional Imaging in Aphasia

Eligibility

Inclusion criteria

Inclusion criteria: 1. Aphasia after stroke, determined by neurologist/ rehabilitation physician and speech and language therapist; 2. 6 months. Additional inclusion criteria for patients participating in a neuroimaging study (FIAT), subpart of RATS-3: 1. Chronic patients 1-3 years post-stroke.

Exclusion criteria

Exclusion criteria: 1. Pre-existing aphasia; 2. Subarachnoid/subdural haemorrhage/hematoma; 3. Severe threats to the success and/or feasibility of language therapy: A. Severe dysarthria; B. Premorbid dementia; C. Illiteracy; D. Severe developmental dyslexia; E. Severe visual perceptual disorders; F. Recent psychiatric history. Additional exclusion criteria for patients participating in a neuroimaging study (FIAT), subpart of RATS-3: 1. Age >80; 2. Left handedness or ambidexterity; 3. Bilingualism; 4. Prior stroke (acute patients only); 5. Contraindications for MR imaging; 6. Severe motor disability (inability to make independent transfers); 7. Cortical lesions in the right hemisphere as assessed by MRI.

Design outcomes

Primary

Measure	Time frame
The difference in score on the ANELT post therapy (4½ -6 weeks post onset) between the two groups.	—

Secondary

Measure	Time frame
1. The difference in score on the semantic and phonologic tests: Semantic Association Test verbal version, Semantic Word Fluency, Letter Fluency, Nonwords repetition, Auditory Lexical Decision post therapy (4½ -6 weeks p.o.) and 3 months p.o. between groups and the difference in score on the ANELT 3 months p.o.; 2. The difference in score on the semantic and phonologic tests: Semantic Association Test verbal version, Semantic Word Fluency, Letter Fluency, Nonwords repetition, Auditory Lexical Decision 6 months p.o. between groups and the difference in score on the ANELT 6 months p.o.	—

Measure

Time frame

1. The difference in score on the semantic and phonologic tests: Semantic Association Test verbal version, Semantic Word Fluency, Letter Fluency, Nonwords repetition, Auditory Lexical Decision post therapy (4½ -6 weeks p.o.) and 3 months p.o. between groups and the difference in score on the ANELT 3 months p.o.; 2. The difference in score on the semantic and phonologic tests: Semantic Association Test verbal version, Semantic Word Fluency, Letter Fluency, Nonwords repetition, Auditory Lexical Decision 6 months p.o. between groups and the difference in score on the ANELT 6 months p.o.

—

Contacts

Public ContactFemke Nouwens

Erasmus MC Afd. Neurologie, kamer Ee2291 Postbus 2040

+31 (0)10 7043414

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)