Activity of brown adipose tissue during hypoglycaemia.

Activity of Brown Adipose Tissue during hypoglycaEmia.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON23492

Enrollment

Registered

2011-02-09

Start date

2011-03-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 1 Diabetes, Brown Adipose Tissue, Thermoregulation, Type 1 Diabetes, bruin vet, thermoregulatie

Interventions

Two 18F-FDG PET-CT scans per patient will be performed of the upper body half to visualise the activity of BAT. The first scan will be performed following a hyperinsulinaemic normoglycaemic clamp and

Eligibility

Inclusion criteria

Inclusion criteria: Inclusion criteria for healthy volunteers: 1. Male; 2. Caucasian race; 3. 18-50 years old; 4. BMI 20-28 kg/m2; 5. Subjects should be able and willing to give informed consent. Inclusion criteria for type 1 Diabetes patients: 1. Male; 2. Caucasian race; 3. Age 18-50 years; 4. BMI 20-28 kg/m2; 5. Type 1 Diabetes Mellitus; 6. Subjects should be able and willing to give informed consent.

Exclusion criteria

Exclusion criteria: Exclusion criteria for healthy volunteers: 1. Use of prescription medication (beta-adrenoreceptor blockers); 2. Cardiac history (previous arrhythmia); 3. History of epilepsy; 4. Acute illness within 3 months before the study; 5. Significant renal impairment (creatinin clearance <50ml/min); 6. Family history of diabetes. Exclusion criteria for type 1 Diabetes patients: 1. Impaired awareness of hypoglycaemia; 2. Evidence of severe diabetes complications (autonomic neuropathy, macroalbuminuria, proliferative retinopathy); 3. Use of beta-adrenoreceptor blockers; 4. Cardiac history (previous arrhythmia); 5. History of epilepsy; 6. Acute illness within 3 months before the study; 7. Significant renal impairment (creatinin clearance <50ml/min).

Design outcomes

Primary

Measure	Time frame
1. Change in Standardised Uptake Value (SUV) of the tracer [18F]-fluorodeoxyglucose (FDG) visualised with positron emission tomography (PET) in BAT (normoglycaemia vs. hypoglycaemia); 2. Change in Standardised Uptake Value (SUV) of the tracer [18F]-fluorodeoxyglucose (FDG) visualised with positron emission tomography (PET) in BAT (healty volunteers vs. type 1 Diabetes patients).	—

Contacts

Public ContactF. Holleman

Postbus 22660

F.Holleman@amc.uva.nl+31 (0)20 5665954

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)