Changes in lung function en exhaled breath after exposure to oxygen at high atmospheric pressure.

Changes in VC, DLCO, DLNO and exhaled breath after an one-hour oxygen dive with a PO2 of 190 kPa as an indication for pulmonary oxygen toxicity.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON23480

Enrollment

Registered

2011-10-18

Start date

2011-11-01

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pulmonary oxygen toxicity diffusing capacity spirometry exhaled breath

Interventions

Every subject will perform one dive with air and one with 100% oxygen. These dives will be done in random order.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adult males; 2. Professional divers; 3. Fit to dive; 4. Certified Oxygen divers or those who were granted dispensation for oxygen diving; 5. FEV1/SVC minimal 70 (absolute); 6. DLco % reference > 70%.

Exclusion criteria

Exclusion criteria: 1. If one of the inclusion criteria is not met; 2. Recent lower respiratory tract infection and/or flue; 3. Daily use of alcoholic beverages.

Design outcomes

Primary

Measure	Time frame
Changes in DLno and DLco compared to baseline after air and oxygen dives.	—

Secondary

Measure	Time frame
1. Changes in VC, Dm, VC, EB compared to baseline after air and oxygen dives; 2. Changes in oxidative stress status compared to baseline after air and oxygen dives.	—

Contacts

Public ContactP.J.A.M. Ooij, van

PO Box 10000

pjam.v.ooij.01@mindef.nl+31 (0)22 3653076

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)