Severe mental illness
Conditions
Interventions
Genetic counseling (GC)
Genetic counseling + provision of a polygenic risk score (GC-PRS)
Control group: care as usual
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: (1) The participant has been diagnosed with SMI, which is defined as having a psychosis spectrum disorder or bipolar disorder, or is a first-degree family member of a patient diagnosed with SMI. (2) The participant is at least 16 years old; (3) The participant must be able to speak and read the Dutch language; (4) The participant must be mentally competent and have decisional capacity with regard to a decision in participating in the current study, which will be assessed by the (treating) physician.
Exclusion criteria
Exclusion criteria: (1) The participant is admitted involuntary to a psychiatric unit in the context of a ‘crisismaatregel’; (2) The participant was previously diagnosed with a clinically relevant genetic diagnosis; (3) The experienced psychiatric episode was primarily substance-induced.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Risk perception, knowledge, empowerment, self-stigma, (motivation to change) health-related behavior | — |
Secondary
| Measure | Time frame |
|---|---|
| Attitudes towards genetic counseling and polygenic risk scores in psychiatry | — |
Contacts
Public ContactMarte van der Horst
UMC Utrecht
Outcome results
None listed