Dystonia Myoclonus/jerks Psychiatric co-morbidity (e.g. depression, anxiety disorders) Dystonie Myoclonieen of schokken Psychiatrische aandoeningen, zoals depressie en angsstoornissen
Conditions
Interventions
Subjects are randomly assigned to first receive one of the following treatment regimens for a period of 6 weeks:
1. Escitalopram 10 mg tablets orally
2. Placebo tablets orally.
After a washout period of 6 weeks the interventions will be switched: the patients who received escitalopram will receive placebo and vice versa. Because of the crossover d
Sponsors
Academic Medical Center, University of Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 80 years old; 2. Informed consent; 3. Primary dystonia treated with botulinum toxin injections in the Academic Medical Center; 4. Stable Tsui scale for severity of dystonia for at least one year.
Exclusion criteria
Exclusion criteria: 1. Other neurological conditions at inclusion or in the past; 2. Use of medication or drugs with a known effect on the execution of tasks, besides anti-epileptic drugs; 3. Treatment with deep brain stimulation for dystonia; 4. SSRI use in the past 6 months prior to or during the study; 5. Use of other anti-depressants during the study, especially MAO-B inhibitors; 6. Symptomatic therapy for dystonia other than botulinum toxin; 7. Use of medication with a known effect on dopamine or serotonin receptors or transporters or with a known interaction with escitalopram; 8. Pregnancy or nursing.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients that change at least 1 point on Clinical Global Impression scale after treatment on jerks. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Type of psychiatric co-morbidity in dystonia patients; 2. Number of points change on CGI scale before and after treatment on psychiatric symptoms and dystonia; 3. Number of points change on neurological and psychological scales. | — |
Contacts
Public ContactMAJ Koning-Tijssen, de
Postbus 22660
Outcome results
None listed