drugs, blood pressure, hypertension, compliance, treatment resistance, MEMS monitors
Conditions
Interventions
MEMS monitors are caps of pill boxes which record time and date of every opening of the pill box. Assuming that every opening is a single dose intake, a dosing history of a patient can be recorded dur
Sponsors
This is an investigator-driven study.
Principal Investigator: prof. dr. P.W. de Leeuw
Co-investigators: dr. P. Nelemans and dr. A.A. Kroon
Eligibility
Inclusion criteria
Inclusion criteria: - Eligible are patients who have drug-resistent hypertension and have no renal artery stenosis (must have been excluded by conventional renal angiography or CT angiography or MR angiography). Drug resistant hypertension is defined as having mean blood pressure >130/80 mm Hg according to 24-hour ambulatory blood pressure measurements (ABPM) despite the use of three or more drugs.
Exclusion criteria
Exclusion criteria: - Patient that do not meet the inclusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure will be the proportion of patients who reach the target levels at 6 months after inclusion (question 1 and 2) and at one year after inclusion (question 3). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures are: - The proportion of patients with substantial decrease in blood pressure (SBP > 10 mm Hg and/or DBP > 5 mm Hg) - The compliance rate defined as percentage of days with correct number of dosing and prescribed number and doses of antihypertensive drugs. | — |
Contacts
Public ContactA.A. Kroon
Academisch Ziekenhuis Maastricht Department of Internal Medicine
Outcome results
None listed