Bradycardia, Heart Failure, Left bundle branch block
Conditions
Interventions
Left bundle branch area pacing
Sponsors
Medtronic
Eligibility
Inclusion criteria
Inclusion criteria: Indication for permanent cardiac pacing: o pacing indication in structurally normal heart because of: • sinus node dysfunction (SND) • atrioventricular block (AVB) • atrial tachy-arrhythmia refractory to anti-arrhythmic medications that required atrioventricular node ablation o Pacing indication with reduced LV ejection fraction • pacing indication with reduced LV ejection fraction and expected high percentage of ventricular pacing • heart failure with wide QRS and LBBB and reduced LVEF
Exclusion criteria
Exclusion criteria: • Age < 18 years • Incapable of giving informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To demonstrate superiority of left ventricular septal pacing (LVSP) over RV pacing and to investigate the additional effect of capturing the left bundle branch in LVSP. This will be done by studying differences in electrophysiological and hemodynamic effects of different LV septal pacing lead penetration depths. | — |
Secondary
| Measure | Time frame |
|---|---|
| • Study the global and regional strain patterns measured by echocardiography during LVSP. • Compare effects of LVSP between patients with structurally normal hearts and patients with reduced LV ejection fraction. • To study ventricular remodelling assessed through echocardiography after three months in all patients. | — |
Contacts
Public ContactLuuk Heckman
Maastricht University
Outcome results
None listed