Effect of Sodium NItroprusside (SNP) on R,S] and S]Ketamine]induced psychotropic side effects, hemodynamic changes and pain relief in healthy volunteers

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON23422

Enrollment

Registered

2015-08-11

Start date

2015-04-20

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Psychomimetic side effects ketamine

Interventions

Part 1: Sodium nitroprusside(SNP) or placebo will be administered intravenously started 60 minutes prior to intravenous administration of ketamine, and will be terminated when the ketamine infusion is

Eligibility

Inclusion criteria

Inclusion criteria: Male subjects, aged 18]34 years with a body mass index < 30 kg/m2

Exclusion criteria

Exclusion criteria: Severe medical disease including hypertension, liver/renal disease, neurological disorders, diaphragmatic hernia/pyrosis; (history of) psychiatric or neurological disease; allergy to study medication; (history of) illicit drug abuse/alcoholism.

Design outcomes

Primary

Measure	Time frame
psychomimetic side effects evaluated by Bowdle and Bond & Lader.	—

Secondary

Measure	Time frame
-Hemodynamic response as evaluated by mean arterial pressure and cardiac output. - Analgesia (pressure and electrical) -Arterial blood samples (pharmacokinetic study)	—

Contacts

Public ContactAlbert Dahan

Leiden University Medical Center (LUMC), Department of Anesthesiology, P.O. Box 9600

a.dahan@lumc.nl+31 (0)71 5262301

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)

Effect of Sodium NItroprusside (SNP) on R,S] and S]Ketamine]induced psychotropic side effects, hemodynamic changes and pain relief in healthy volunteers