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Studie naar de relatie tussen elektrische signalen, bloedwaarden en weefsel eigenschappen en het ontwikkelen van boezemfibrilleren.

Hsf1 Activators Lower cardiomyocyte damage: Towards a novel therapeutic approach to REVERSE atrial fibrillation

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
NL-OMON
Registry ID
NL-OMON23418
Enrollment
300
Registered
2014-06-12
Start date
2014-09-01
Completion date
Unknown
Last updated
2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation Epicardial Mapping Heat Shock Protein Cardiac Surgery Pulmonary Vein Isolation Electrical Cardioversion

Interventions

In patients undergoing cardiac surgery: - Epicardial mapping - Biopsie atrial appendage In patients undergoing pulmonary vein isolation: - Endovascular mapping In all patients: bloodsamples for H

Sponsors

Grant from the european union
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult (>18 yr) patients undergoing elective cardiac surgery, pulmonary vein isolation or electric cardioversion

Exclusion criteria

Exclusion criteria: Paced Atrial Rhythms Hemodynamic Instability Presence of Assist Devices Usage of Inotropic Agents Emergency Cardiac Surgery Redo Cardiac Surgery

Design outcomes

Primary

MeasureTime frame
Main endpoint of the study is development or recurrence of AF, or completion of five year follow up period. We will test the correlation between HSP levels and development or recurrence of AF, and the correlation between degree of electropathology and development/recurrence of AF.

Secondary

MeasureTime frame
The relationship between the atrial conduction pattern as visualised by epicardial mapping and structural tissue characteristics will be tested.

Contacts

Public ContactN.M.S. Groot, de

's Gravendijkwal 230

n.m.s.degroot@erasmusmc.nl+31 (0)10 7034479

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)