stroke, post-stroke epilepsy, cognitive deterioration. Beroerte, epilepsie na beroerte, cognitieve achteruitgang.
Conditions
Interventions
none
Sponsors
Prof.Dr. Robert v Oostenbrugge, Department of Neurology, Maastricht University Medical Centre+ (MUMC+)
Eligibility
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: - patients suffering from post-stroke epilepsy after cortical stroke defined as one or more unprovoked epileptic seizures occurring more than one week after the stroke, according to International League Against Epilepsy criteria(22), with the onset of clinical stroke symptoms less 2 years prior to inclusion. -Patients suffering from cortical stroke, with the onset of acute stroke symptoms between 4 months and 2 years prior to inclusion. -Age 40-70 years
Exclusion criteria
Exclusion criteria: A potential subject (PSE or control) who meets any of the following criteria will be excluded from participation in this study: -primary intracerebral hemorrhage -hemorrhagic transformation of stroke of any clinical significance -previous history of epilepsy -history of another cerebral disorder (neurodegenerative diseases, tumours) -inability to provide informed consent - any contraindication for MRI: metallic foreign body, pacemaker, claustrophobia, pregnancy, tattoos, permanent make-up. - known contrast allergy to gadolinium, insufficient kidney function (eGFR<=30).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - BBB permeability as determined by DCE-MRI to assess the leakiness of the cerebral vasculature by dynamically measuring the rate of contrast agent transfer from blood into the interstitial space (leakage rate; units: mL / (min 100 g tissue)). We will compare BBB permeability in PSE patients with non-PSE. - Resting state functional MRI: connectivity measures, locally as well as whole brain network analysis (using graph theoretical measures) as well as DTI connectivity measures, locally (mean diffusivity/fractional anisotropy) and anatomical features (measured by standard T2, SWI and FLAIR sequences: gliosis, iron deposits microbleeds, dilated perivascular spaces, and cortical and subcortical ischemic lesions). | — |
Secondary
| Measure | Time frame |
|---|---|
| - Stroke and post-stroke epilepsy outcome will be assessed using the NIHSS. -All patients and healthy controls will undergo cognitive testing, focussed on assessing central processing speed using the CVST (Grevers et al., 2016 ). In addition the highest premorbid educational level will be determined . Laesional deficits (such as dysphasia) will be tested at inclusion. | — |
Contacts
Public ContactR. Rouhl
PO Box 5800
Outcome results
None listed