Effects of inspiratory muscle training in patients with chronic obstructive pulmonary disease.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON23400

Enrollment

166

Registered

2011-07-18

Start date

2011-09-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COPD, inspiratory muscle weakness ademhalingsspierzwakte

Interventions

Additional to general pulmonary rehabilatation prpgram: Inspiratory muscle training at a high intensity (&#8805

30% PI,max), whereas the control group will receive an inspiratory muscle training intervention at a low training intensity (&#8804

10% PI,max).

Eligibility

Inclusion criteria

Inclusion criteria: 1. COPD; 2. Inspiratory muscle weakness (Pimax < 60cm H2O).

Exclusion criteria

Exclusion criteria: 1. Diagnosed psychiatric or cognitive disorders; 2. Progressive neurological or neuromuscular disorders; 3. Severe orthopedic problems having a major impact on daily activities; 4. Patients on the waiting list for lung transplantation; 5. Hospitalization during the previous month; 6. Previous inclusion in rehabilitation program (<1 year).

Design outcomes

Primary

Measure	Time frame
6mwd.	—

Secondary

Measure	Time frame
The effects of adding IMT to a 3-months general exercise training program will be compared with a regular 3-months general exercise training program on HRQL and participation in daily physical activity in patients with COPD and inspiratory muscle weakness. Improvements in health-related quality of life as assessed with the disease specific chronic respiratory disease questionnaire (CRDQ) and participation in objectively assessed daily physical activity and breathing pattern during exercise will be secondary outcomes. Tidal volume (VT), inspiratory time (TI), total time of the respiratory cycle (TTOT) and respiratory frequency (fR) will be assessed as parameters reflecting breathing pattern of patients. TI/TTOT (duty cycle) represents the time fraction during which the inspiratory muscles are active. Threshold IMT is supposed to lower this fraction thereby leaving more time for expiration potentially leading to less dynamic hyperinflation. Furthermore the fR/VT ratio will be monitored to assess whether breathing during exercise becomes less rapid and less shallow after IMT.	—

Measure

Time frame

The effects of adding IMT to a 3-months general exercise training program will be compared with a regular 3-months general exercise training program on HRQL and participation in daily physical activity in patients with COPD and inspiratory muscle weakness. Improvements in health-related quality of life as assessed with the disease specific chronic respiratory disease questionnaire (CRDQ) and participation in objectively assessed daily physical activity and breathing pattern during exercise will be secondary outcomes. Tidal volume (VT), inspiratory time (TI), total time of the respiratory cycle (TTOT) and respiratory frequency (fR) will be assessed as parameters reflecting breathing pattern of patients. TI/TTOT (duty cycle) represents the time fraction during which the inspiratory muscles are active. Threshold IMT is supposed to lower this fraction thereby leaving more time for expiration potentially leading to less dynamic hyperinflation. Furthermore the fR/VT ratio will be monitored to assess whether breathing during exercise becomes less rapid and less shallow after IMT.

—

Contacts

Public ContactH.A.C. Helvoort, van

PO box 66

H.vanHelvoort@LONG.umcn.nl+31 (0)24 6859214

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)