Colorectaal carcinoom, Darmpoliepen, Poliepen, Adenomen, Vlak, Non-polypoid, Laterally Spreading Tumors, Serrated lesions
Conditions
Interventions
Sponsors
Maastricht University Medical Center (MUMC+), Department of Gastroenterology and Hepatology
Eligibility
Inclusion criteria
Inclusion criteria: Patients referred for routine colonoscopy with or without positive familiy history for colorectal cancer.
Exclusion criteria
Exclusion criteria: Patients with a history of inflammatory bowel disease, polyposis syndrome and proved mutations (APC, MUTYH, MMR) are excluded from analysis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Prevalence of flat colorectal lesions in a Dutch population, especially the prevalence of Laterally Spreading Tumors; 2. Clinical characteristics (e.g. location of lesions, percentage of high-grade dysplasia or early cancer); 3. Molecular charcteristics (epigenetic: methylation status and genetic) of flat vs. polypoid colorectal lesions; 4. Prevalence of flat advanced colorectal cancers vs. polypoid advanced colorecal cancers: clinical features of these lesions (e.g. tumor stage); 5. Relation between serrated and adenomatous polyps. | — |
Secondary
| Measure | Time frame |
|---|---|
| Prevalence and genotype and fenotype associations of flat colorectal lesions in patients at high-risk for colorectal cancer. | — |
Contacts
Public ContactR.M.M. Bogie
Maastricht University Medical Center, Postbus 5800, 6202 AZ Maastricht
Outcome results
None listed