Comparitive study of the stability of oral anticoagulant therapy using phenprocoumon or warfarin.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON23351

Enrollment

500

Registered

2005-09-09

Start date

2004-03-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Treatment group: oral anticoagulant treatment with warfarin. Control group: oral anticoagulant treatment with phenprocoumon.

Eligibility

Inclusion criteria

Inclusion criteria: 1. No current use of anticoagulants; 2. Aged 18–85; 3. Indication for the use of oral anticoagulants; 4. Living in the workingarea of the Leiden Anticoagulation Clinic; 5. Adequate intelligence, informed consent.

Exclusion criteria

Exclusion criteria: 1. Pregnancy; 2. Chemotherapy; 3. Hemo- of peritoneal dialysis; 4. Plasmafereses; 5. Contra-indication for the use of oral anticoagulants.

Design outcomes

Primary

Measure	Time frame
Time spent within therapeutic range, time to the first INR in range, percentage of INRs above range after initiation scheme, reaction of INR to interruption of coumarin or vitamin K administration.	—

Secondary

Measure	Time frame
1. Bleeding complications; 2. Thrombotic complications.	—

Contacts

Public ContactY. Leeuwen, van

Leiden University Medical Center (LUMC), Department of Clinical Epidemiology, P.O. Box 9600

y.van_leeuwen@lumc.nl+31 (0)71 5261384

Outcome results