Atopic dermatitis
Conditions
Interventions
Patients are instructed to apply Dermalex eczema cream, a standard emollient or a dermatocorticosetroid on one side of the body on atopic dermatitis lesions at least twice a day. The opposite side wil
Sponsors
AMC
Eligibility
Inclusion criteria
Inclusion criteria: - Clinically diagnosed atopic dermatitis - Mild to moderate atopic dermatitis, according to total SCORAD score (score <25 and <50 respectively) - Age between 18 and 70 years - Written informed consent - At least two symmetrical (i.e. left and right side of the body) skin sites with comparable AD severity (Measured in SCORAD-score)
Exclusion criteria
Exclusion criteria: - Extensive UV exposure in the last 14 days before study and/or expected during the study. - Other skin disease other than AD. - Use of antibiotics prior to (4 weeks) the study and/or expected use during the study. - Use of systemic suppressing drugs (e.g. prednisone, methothrexate) prior to (4 weeks) the study and/or expected use during the study -Severe disorders within the last 6 months before study (e.g. cancer, acute cardiac or circularity disorders, HIV, infectious hepatitis) - Investigator's uncertainty about the willingness or ability of the patient to comply with the protocol requirements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changed 22-may-2015: 1) Change in modified SCORAD in three and six weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| - The amount of used cream/ointments (per day and total) - Change in cytokine levels, lipid profile, Trans epidermal water loss and PH after the different treatments. - presence of mutations on the Fillagrin-gene | — |
Contacts
Public ContactS.A. Koppes
Coronel Institute of Occupational Health Academic Medical Center, AMC K0-116 Meibergdreef 9
Outcome results
None listed