cardiac arrest, therapeutic hypothermia, neuromuscular blockade, train-of-four, pancuroniumbromide
Conditions
Interventions
Pancuroniumbromide infusion during 24 hours.
Sponsors
Maastricht University Medical Centre
Eligibility
Inclusion criteria
Inclusion criteria: Patient criteria: 1. Age > 18 years. Cooling criteria: 1. Witnessed cardiac arrest; 2. Initial cardiac rhythm being VF/VT; 3. Delay from arrest till start CPR >5min, <15min; 4. Time from arrest till return of spontaneous circulation (ROSC) <60min; 5. Start cooling within 6 hours after ROSC.
Exclusion criteria
Exclusion criteria: Exclusion from cooling (MUMC based): 1. Cardiac shock >30min after ROSC; 2. Coma before cardiac arrest; 3. Other cause of coma (CVA, trauma, intoxication); 4. Hypothermia on arrival at emergency department (15min after ROSC; 8. Terminal disease state; 9. Pre-existing coagulation disorders (trombolysis is no contra-indication); 10. Persistent ventricular arrhythmias. Exclusion because of study criteria: 1. Age < 18 years; 2. Contraindications for use of pancuronium; 3. No option for neuromuscular monitoring on at least one hand; 4. Use of confounding medication (anticonvulsants, steroid therapy, verapamil or aminoglycosides); 5. Renal failure; 6. Liver failure; 7. Neuromuscular diseases; 8. Use of other neuromuscular relaxants than pancuronium.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Median during untill TOF ratio 0.9 after 24 hours of pancuroniumbromide infusion. | — |
Contacts
Public ContactL.P.W. Mommers
Maastricht University Medical Centre P. Debyelaan 25
Outcome results
None listed