platelets under pressure

what is the influence of pressure, heat and the combiation of both on the function platelets concentrated for the purpose of transfusion.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON23327

Enrollment

Registered

2013-10-08

Start date

2013-10-14

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

rapid transfusion (snel transfusie), platelet function (platjes functie), heat application (wamrte aplicatie), pressure application (druk applicatie)

Interventions

We mimick the rapid infusion of blood products in urgent situations where red packed cells are warmed and infusied under pressure by applying 1. pressure (150 mmHg) 2. heat (37-39 degree Celsius)

Eligibility

Inclusion criteria

Inclusion criteria: 10 platelet concentrates with the same age

Exclusion criteria

Exclusion criteria: concentrate with different ages

Design outcomes

Primary

Measure	Time frame
In vitro platelet function measurement assessed by multiple impedance aggregometrie (MEA-Multiplate Multiple aggregometer Dynabyte Medical Munich, Germany)) and light transmission aggragometrie (LTA-platelet aggregometer PAR-4 Hart Biologicals Ltd Hartlepool, UK)). Both function tests will be performed before and after the test condition (see above).	—

Secondary

Measure	Time frame
microparticle content measured by ELISA (ZYMUPHEN, MP-activity kit, Aniara, Mason, Ohio, USA) pH, glucose and lactate measured in the Chiron rapid lab 850 blood gas analyser (Siemens Healthcare Diagnostics, Breda, the Netherlands)	—

Contacts

Public ContactM.D. Lancé

dept of anesthesiology MUMC+ P.Debeyelaan 25

marcus.lance@mumc.nl

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)