Intracerebral hemorrhage and dementia
Conditions
Interventions
N.A.
Sponsors
LUMC
Eligibility
Inclusion criteria
Inclusion criteria: ICH patients: 1. Age = 55y 2. Ability and willingness to provide written informed consent. 3. Supratentorial ICH with CAAa or HAb as the most likely cause. a CAA-related ICH is defined as an ICH that meets the criteria for definite or probable CAA according to the Modified Boston Criteria (appendix A) b HA-related ICH is defined as ICH located in the basal ganglia, thalamus, or the deep white matter and the presence of hypertension defined as: on treatment for hypertension, or known with high blood pressure (two measurements SBP >140 or DBP >90 mmHg) but not treated for hypertension.
Exclusion criteria
Exclusion criteria: 5.3 Exclusion criteria 1. Age < 55y 2. Unable to provide informed consent. 3. Pre-existing cognitive impairment assessed with the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE); scores between 53 - 63 reflect pre-existing cognitive mpairment. 4. Contra indications, such as: Contra-indications for 3T MRI and contraindications for lumbar puncture:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main parameters are cognitive decline (according to the neuropsychological assessment) at 12 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are burden of SVD markers on MRI and CSF markers at baseline, at six months and 12 months. | — |
Contacts
Public ContactEllis van Etten
Leiden University Medical Center
Outcome results
None listed