Stable severe and mild asthma, respiratory tract infections.
Conditions
Interventions
A review of the medical history, physical examination, standard spirometry, post-bronchodilator spirometry and/or a methacoline challenge will be performed.
The enrolled patients will undergo several
Sponsors
Academic medical Center (AMC)
Eligibility
Inclusion criteria
Inclusion criteria: MILD Asthmatic patients: 1. Able to give written and dated informed consent prior to any study specific procedure 2. Men and/or women age between 18-65 years 3. History of episodic chest tightness and wheezing 4. Prebronchodilator FEV 1 ≥80% predicted 5. Reversibility in FEV1>12% predicted, or documented hyperesponsiveness (PC20 methacoline 12% predicted, or documented hyperesponsiveness (PC20 methacoline 8mg/ml) 5. Negative history of pulmonary and any other relevant diseases
Exclusion criteria
Exclusion criteria: Exclusion criteria for all the groups are: 1. History of current alcohol or drug abuse, as judged by the investigator. 2. Subjects who have had an exacerbation or a chest infection within the last 4 weeks prior to the study. 3. Uncontrolled hypertension-systolic blood pressure(BP)>200 mmHg and/or diastolic BP>100 mmHg. 4. Concomitant disease or condition which could interfere with the conduct of the study or which would, in the opinion of the investigator, pose an unacceptable risk to the patient in this study. 5. Unwillingness or inability to comply with the study protocol for any other reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the prevalence of latent infections by non invasive assessment of induced sputum, exhaled breath condensate and nasal/throat swabs in stable asthmatic patients and controls. | — |
Secondary
| Measure | Time frame |
|---|---|
| To value whether the presence and types of bronchial pathogens are associated with clinical severity of asthma and to determine whether the assessment of latent infections can be reproduced after six weeks and twelve weeks from the first measurement. | — |
Contacts
Public ContactPeter J. Sterk
Dept. Pulmonology, F5-259 Academic Medical Center University of Amsterdam P.O. Box 22700
Outcome results
None listed