colorectal cancer, colorectal neoplasia, colorectal neoplasms, high risk population, family history
Conditions
Interventions
Collection of blood and fecal samples (once). Non-invasive markers for colorectal neoplasia will be determined in blood, feces and tissue. All combinations of markers will be tested in order to optimi
Sponsors
Maastricht University Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: - This population will include patients with hereditary forms of CRC (Lynch syndrome or FAP) as well as patients fulfilling the criteria for familial CRC syndrome: i) ³ 1 first degree relative (FDR) with CRC diagnosed < 50 year or ii) ³ 2 FDR with CRC diagnosed between 50-70 year or iii) 1 FDR and 1 second degree relative with CRC diagnosed < 70 year. - Furthermore patients diagnosed with CRC will be included.
Exclusion criteria
Exclusion criteria: Individuals will be excluded if: 1. Younger than 18 years of age 2. Diagnosed with inflammatory bowel disease (Crohn’s disease or ulcerative colitis) 3. Diagnosed with major co-morbidity which may interfere with the outcome of the study (e.g. severe cardiovascular or pulmonary disease, other malignancies)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic accuracy of molecular and protein markers in screening for colorectal neoplasia in subjects at high-risk for CRC and CRC patients, in comparison with average-risk subjects. | — |
Secondary
| Measure | Time frame |
|---|---|
| The role of non-invasive markers in risk stratification of patients at high-risk for CRC. | — |
Contacts
Public ContactS. Sanduleanu
University Hospital Maastricht Department of Gastroenterology and Hepatology PO BOX 5800
Outcome results
None listed