Obsessive Compulsive Disorder
Conditions
Interventions
None listed
Sponsors
NWO
Eligibility
Inclusion criteria
Inclusion criteria: OCD subjects: - DSM-5 diagnosis of OCD - No other psychiatric disorder - Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) score cut-off of 12 assessed by the treating therapist. This cut-off score has been chosen, since it allows us to achieve an increased degree of variability in the severity of the symptoms and thus to examine individual differences more closely. - 18-65 years of age - Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements - Access to internet with their own pc or laptop from home to perform online tasks and fill in online questionnaires HC subjects: - No current psychiatric diagnosis or history of OCD. - 18-65 years of age - Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements - Access to internet with their own pc or laptop from home to perform online tasks and fill in online questionnaires
Exclusion criteria
Exclusion criteria: - Current major depressive disorder, bipolar disorder, psychotic disorder, alcohol or substance dependence, or any cognitive disorder as assessed with the MINI neurological disorders section - IQ below 80 - Insufficient command of the Dutch language - Endocrinological disorders or regular use of corticosteroids - Current treatment with SSRIs, tricyclic antidepressant or antipsychotic medication, in order to reduce noise related to medication use. - Use of other psychotropic medication or recent use of recreational drugs over a period of 72 hours prior to each test session, and use of alcohol within the last 24 hours before measurement.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Our overarching main study parameter is the deviation in confidence judgments in OCD patients versus HC subjects. This is studied using four equally important computer tasks, leveraging the following four study parameters 1)The difference in confidence levels in symptom-related context versus neutral context. 2)The coupling between confidence and learning within a volatile environment. 3)The influence of post-decisional evidence on confidence level updating (i.e. changes of mind). 4)Global self-confidence and the relationship to local confidence levels. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) YBOCS scores (OCD symptoms) | — |
Contacts
Public ContactMonja Hoven
Amsterdam UMC locatie AMC
Outcome results
None listed