Effects of folic acid on the human microcirculation: a randomized, doubleblind, placebo-controlled study.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON23261

Enrollment

Registered

2006-10-19

Start date

2006-11-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

1. Folic acid 0,5 mg daily during 8 weeks

2. 5-methyltetrahydrofolate 5 mg once.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age: 25-55; 2. BMI > 25 and BMI < 30; 3. causcasian.

Exclusion criteria

Exclusion criteria: 1. Medication affecting cardiovascular function; 2. systolic bloodpressure > 160; 3. diastolic bloodpressure > 95; 4. diabetes mellitus; 5. anemia; 6. renal insufficiency.

Design outcomes

Primary

Measure	Time frame
1. Endothelium-dependent and endothelium-independent skin blood flow using laser-doppler fluxmetry combined with iontophoresis; 2. nailfold video capillaroscopy.	—

Secondary

Measure	Time frame
1. (Ambulatory) blood pressure; 2. vascular resistance; 3. cardiac output.	—

Contacts

Public ContactY.M. Smulders

y.smulders@vumc.nl

Outcome results