Gastroesophageal reflux disease (GERD), hiatal hernia
Conditions
Interventions
Twice a 24 hours ambulatory combined impedance measurement and pH metry (transnasally).
A dose of 3x20mg baclofen and a dose of 3xplacebo
the initial dose consisted of 3 x 5 mg baclofen. Every fourth day, the dose was increased by 5 mg three times daily until a dose of 20 mg three times daily was reached after 10 days.
Sponsors
Academic Medical Center (AMC), Department of Gastroenterology and Hepatology
Eligibility
Inclusion criteria
Inclusion criteria: 1. GERD patients (M/F) with typical heartburn symptoms at least 3 times weekly during the last 3months 2. Daily use of PPIs 3. 18-70 years 4. Hiatal hernia or = 3 cm
Exclusion criteria
Exclusion criteria: 1. Thoracal or upper abdominal surgery 2. Use of drugs which influence gastrointestinal motility 3. Systemical illness which influence esophageal motility 4. Epilepsy 5. Renal function disorder 6. Pregnancy
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| - Total acid exposure time, the composition of the refluxate and the proximal extent of the refluxate | — |
Primary
| Measure | Time frame |
|---|---|
| - The number of reflux episodes (acid and non acid) measured over 24 hours | — |
Contacts
Public ContactH. Beaumont
Academic Medical Center Meibergdreef 9
Outcome results
None listed