ANTIOXIDANTS
Conditions
Interventions
At the start of down regulation treatment or previous cycle precceding the IVF cycle, patients will be randomized into two groups. The antioxidant group (study group) will receive oral antioxidants me
IBSA, Egypt) from cycle day 2 or 3 and continued until the day of ovulation induction. A fixed dose of HP-FSH will be used, either 225 IU - 300 IU per day for the first 5 days, according to age, body
2. Different downrgulation protocols will be used either daily midluteal long GnRH protocol, 01 mg, SC, Decapeptyl( Ferring,) or flexible GnRH antagonist ganirelix (Cetrotide 0.25 mg
Organon) is initiated and continued up to and including the day of ovulation induction
3. When at least two follicles reach a size of 18 mm, both groups will receive hCG (10,000 IU SC) for final oocyte maturation, followed by OPU 34-36 hours later.
Sponsors
Egyptian International Fertility IVF center- Private center, Cairo , Egypt
Eligibility
Inclusion criteria
Inclusion criteria: 1. Female age 18 – 45 years; 2. Menstrual cycles between 25 and 34 days; 3. Absence of uterine abnormalities; 4. Absence of uterine abnormalities; 5. Has an indication for IVF/ICSI.
Exclusion criteria
Exclusion criteria: Poor sperm quality with counts less than 1 million or azospermia.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| 1. Implantation rate; 2. Biochemical and clinical pregnancy rate; 3. Duration of stimulation; 4. Amount of FSH and adverse events. | — |
Primary
| Measure | Time frame |
|---|---|
| 1. Number of retrieved oocytes; 2. Number of mature oocytes; 3. Number of embryos obtained. | — |
Contacts
Public ContactMohamed A.F. Youssef
Post Office Box 109
Outcome results
None listed