Organoids model in laryngeal cancer

A pilot study about culturing laryngeal tumor tissue to facilitate new treatment strategies for laryngeal cancer in future

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON23214

Enrollment

Registered

2020-10-06

Start date

2021-01-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

laryngeal cancer, sentinel lymph node

Interventions

Biopsies will be taken at the departments of Otolaryngology / Head and Neck Surgery or Maxillofacial Surgery of the University Medical Center Groningen. During routine biopsy or resection, additional

Eligibility

Inclusion criteria

Inclusion criteria: - proven carcinoma of the larynx - > 18 yrs of age - planned routine biopsy or planned surgical resection as part of standard diagnostic work-up or treatment - expected tumor volume > 2 cm3 - informed consent

Exclusion criteria

Exclusion criteria: - non-squamous cell carcinoma after definitive histological analysis

Design outcomes

Primary

Measure	Time frame
We want to further develop and evaluate our patients’ specific ex vivo LC organoids in which at least 50% of the obtained tumor samples are viable and proliferating at week 2 and 6.	—

Secondary

Measure	Time frame
We will analyse differences in solidity of ex vivo LC organoids between primary and recurrent LC tissue.	—

Contacts

Public ContactConstanze Scholman

Universitair Medisch Centrum Groningen

c.scholman@umcg.nl(050) 361 61 61

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)